Official vehicle configuration guide

2025 Mercedes-Benz E-Class

Compare 5 EPA-tested configurations, including the exact powertrain, fuel, driven wheels, engine, transmission and efficiency data available for this model year.

U.S. market 5 EPA configurations Plug-in hybridHybrid
Official EPA configuration data

Choose the closest tested configuration.

These entries distinguish powertrains and driveline combinations recorded by the U.S. EPA. They help narrow the vehicle, but they are not guaranteed retail trim or option-package names.

5 configurations
Match the fuel type, drive and transmission shown on the vehicle documents. A dealer package may use a different name.
Selected configurationAMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG
Plug-in hybrid
Fuel
Premium and Electricity
Engine
SIDI; PHEV · turbocharged
Drive
AWD
Transmission
Automatic 9-spd
EPA combined
23 MPG combined
City / highway
21 / 26 MPG
Electric motor
120 kW AC PMSM
Range
43 mi electric · 410 mi total
240 V charge time
2.75 hours
Secondary / blended economy
59 MPGe secondary fuel · 39 MPGe blended
EPA vehicle class
Midsize Cars
Stop-start system
No
Open this configuration on FuelEconomy.gov ↗

AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG selected.

Configuration is not the same as trim. EPA records can separate engines, fuel systems, transmissions or driven wheels without identifying badges such as LX, XLE or Touring. Confirm the retail trim with the window sticker, build sheet or manufacturer VIN portal.

Compare every tested configuration

Mechanical and efficiency differences.

All rows are visible in the page and link to their exact government record. EPA configurations identify tested hardware, not guaranteed retail trim names.

5 official records
Best combined MPG28 MPG

E350 — Hybrid · RWD · 2L 4-cyl · 28 MPG

Longest listed range410 mi

AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG

View all 5 EPA configuration rows
EPA carlinePowertrainEngine / motorDriveTransmissionCombinedRange / chargeSource
AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPGPlug-in hybridPremium and ElectricitySIDI; PHEVAWDAutomatic 9-spd23 MPG21 city / 26 highway43 mi EV / 410 mi total2.75 h at 240 VEPA record ↗
E350 — Hybrid · RWD · 2L 4-cyl · 28 MPGHybridPremiumSIDI; Mild HybridRWDAutomatic 9-spd28 MPG25 city / 33 highway—EPA record ↗
E350 4matic — Hybrid · AWD · 2L 4-cyl · 27 MPGHybridPremiumSIDI; Mild HybridAWDAutomatic 9-spd27 MPG24 city / 33 highway—EPA record ↗
E450 4matic — Hybrid · AWD · 3L 6-cyl · 25 MPGHybridPremiumSIDI; Mild HybridAWDAutomatic 9-spd25 MPG22 city / 31 highway—EPA record ↗
E450 4matic All-Terrain (wagon) — Hybrid · AWD · 3L 6-cyl · 25 MPGHybridPremiumSIDI; Mild HybridAWDAutomatic 9-spd25 MPG22 city / 31 highway—EPA record ↗
At a glance

What the official records cover.

Each option above is tied to a unique FuelEconomy.gov vehicle ID. EPA names sometimes expose a retail badge such as LE or Woodland Edition, but many records identify only the tested mechanical configuration.

01Official carlines

AMG E53 Hybrid 4matic Plus, E350, E350 4matic, E450 4matic, E450 4matic All-Terrain (wagon)

02Powertrains

Plug-in hybrid, Hybrid

03Driven wheels

AWD, RWD

04Engine / motor options

3L 6-cyl, 2L 4-cyl

How to identify yours

Match the hardware before the badge.

  1. 1

    Start with fuel and powertrain. Check whether the vehicle is gasoline, diesel, hybrid, plug-in hybrid, electric or fuel-cell.

  2. 2

    Match driven wheels and engine. Use FWD, RWD, AWD or 4WD plus displacement/cylinder information from the window sticker or registration.

  3. 3

    Confirm the exact EPA record. Select the closest option and open its FuelEconomy.gov link. Use a VIN-specific build sheet when you need the retail trim or option package.

Source: U.S. Department of Energy / EPA FuelEconomy.gov dataset ↗ · U.S. market snapshot 2026-11-04. Economy values are official estimates, not a promise of real-world consumption.

02 Feature research status

The configuration guide is live.

The official mechanical and efficiency data for this exact vehicle is published above. Hidden-feature instructions are a separate layer: they appear only after the correct owner manual, model-year scope and equipment caveats have been checked.

EPA configurations publishedOfficial records linkedOwner-manual features in review
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